I work in Political Economy, and a lot of the models include "innocent" control variables such as population, inequality, colonial legacy, etc. so that the author can claim unbiasedness on their independent variable of interest.
But if any of these control variables are endogenous to some omitted variable, doesn't this contaminate the unbiasedness of ALL the independent variables?
If that's true, then what can we do? Leave those control variables out and they lead to omitted variable bias themselves. Include those in and they will contaminate everything in the model.
Example: A researcher wants to know if inequality leads to violence, and he controls for a few things: \begin{equation} Violence = Inequality + Growth + Development + \epsilon \end{equation} Seeing that Inequality is likely to be endogenous (because of the omitted variable Level of altruism), he will try to find a instrumental variable for Inequality. But aren't Growth and Development likely to be endogenous (i.e. correlated with Level of altruism) too?
This example may look silly, but my point is in Political Economy / Development work, there are so many factors at play (yet omitted) that I'm afraid many variables included on the LHS are endogenous. Yet often, the researcher only looks for an instrument for his pet independent variable only.