I was studying about the Solow Model from Acemoglu. One of the properties of the production function $Y = F(A,K,L)$ is that it exhibits diminishing marginal products. That is, $F_{KK} < 0$ and $F_{LL} < 0$.
Can we also say that $F_{LK} < 0$?
You can't just say that from the diminishing marginal product assumption. $F_{KK}<0$ and $F_{LL}<0$ does not imply that $F_{LK} <0$.
In fact, a standard textbook Cobb-Douglas production function $F= AK^{\alpha}L^{1-\alpha}; 0<\alpha<1$, which is often used together with Solow Swan model will have positive cross derivative, given the parameter restrictions, if any capital and labor is employed:
$$F_{LK}= (1-\alpha)\alpha\frac{A}{(KL)^\alpha} >0 $$
This is despite that the same function has diminishing marginal product for both capital and labor (you can verify that yourself).
Of course, you can play with the model by using different production functions, however, assuming $F_{LK}<0$ is from economic perspective very strange.
$F_{LK}<0$ says that when you increase both the amount of labor and capital in your factory at the same time marginal output declines. For example, if you have sewing factory adding both more sewing machines and more seamsters to operate the sewing machine would result in less shirts produced on the margin. This is very implausible, perhaps there are some special circumstances where you want to assume that but it will not be generally assumed in macroeconomic models that approximate production of whole economy.